abstract：:Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC) migration and tube ...

journal_title：Scientific reports

authors： Yamamizu K,Furuta S,Hamada Y,Yamashita A,Kuzumaki N,Narita M,Doi K,Katayama S,Nagase H,Yamashita JK,Narita M

更新日期：2013-11-14 00:00:00

abstract：:Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...

journal_title：Scientific reports

authors： Ceglarek I,Piotrowicz A,Lecion D,Miernikiewicz P,Owczarek B,Hodyra K,Harhala M,Górski A,Dąbrowska K

更新日期：2013-11-14 00:00:00

abstract：:We investigate the Lorentz-covariant deformed algebra for Dirac oscillator problem, which is a generalization of Kempf deformed algebra in 3 + 1 dimension of space-time, where Lorentz symmetry are preserved. The energy spectrum of the system is analyzed by taking advantage of the corresponding wave functions with expl...

journal_title：Scientific reports

authors： Betrouche M,Maamache M,Choi JR

更新日期：2013-11-14 00:00:00

abstract：:Glyoxalase pathway plays an important role in stress adaptation and many clinical disorders. The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requires either Ni(II)/Co(II) or Zn(II) for activity. Here we have investigated the origin of different metal ion specificities of Gl...

journal_title：Scientific reports

authors： Kaur C,Vishnoi A,Ariyadasa TU,Bhattacharya A,Singla-Pareek SL,Sopory SK

更新日期：2013-11-13 00:00:00

abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...

journal_title：Scientific reports

authors： Fashami MS,Atulasimha J,Bandyopadhyay S

更新日期：2013-11-13 00:00:00

abstract：:Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...

journal_title：Scientific reports

authors： Li J,Xiao X,Xu X,Lin J,Huang Y,Xue Y,Jin P,Zou J,Tang C

更新日期：2013-11-13 00:00:00

abstract：:Nuclear magnetic resonance (NMR) is a fundamental research tool that is widely used in many fields. Despite its powerful applications, unfortunately the low sensitivity of conventional NMR makes it difficult to study thin film or nano-sized samples. In this work, we report the first NMR spectrum obtained from general ...

journal_title：Scientific reports

authors： Won S,Saun SB,Lee S,Lee S,Kim K,Han Y

更新日期：2013-11-12 00:00:00

abstract：:We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...

journal_title：Scientific reports

authors： Yu H,Zhang H,Wang Y,Han S,Yang H,Xu X,Wang Z,Petrov V,Wang J

更新日期：2013-11-12 00:00:00

abstract：:In recent pioneer experiment, a strong spin-orbit coupling, with equal Rashba and Dresselhaus strengths, has been created in a trapped Bose-Einstein condensate. Moreover, many exotic superfluid phenomena induced by this strong spin-orbit coupling have been predicted. In this report, we show that this novel spin-orbit ...

journal_title：Scientific reports

authors： Lian J,Yu L,Liang JQ,Chen G,Jia S

更新日期：2013-11-07 00:00:00

abstract：:Society's increasing interactions with technology are creating extensive "digital traces" of our collective human behavior. These new data sources are fuelling the rapid development of the new field of computational social science. To investigate user attention to the Hurricane Sandy disaster in 2012, we analyze data ...

journal_title：Scientific reports

authors： Preis T,Moat HS,Bishop SR,Treleaven P,Stanley HE

更新日期：2013-11-05 00:00:00

abstract：:Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGG...

journal_title：Scientific reports

authors： Zhao W,Jin L,Yuan H,Tan Z,Zhou C,Li LS,Ma L

更新日期：2013-11-05 00:00:00

abstract：:Horseradish peroxidase (HRP) mediates efficient conversion of many phenolic contaminants and thus has potential applications for pollution control. Such potentially important applications suffer however from the fact that the enzyme becomes quickly inactivated during phenol oxidation and polymerization. The work here ...

journal_title：Scientific reports

authors： Mao L,Luo S,Huang Q,Lu J

更新日期：2013-11-04 00:00:00

abstract：:Magnesium battery is potentially a safe, cost-effective, and high energy density technology for large scale energy storage. However, the development of magnesium battery has been hindered by the limited performance and the lack of fundamental understandings of electrolytes. Here, we present a study in understanding co...

journal_title：Scientific reports

authors： Shao Y,Liu T,Li G,Gu M,Nie Z,Engelhard M,Xiao J,Lv D,Wang C,Zhang JG,Liu J

更新日期：2013-11-04 00:00:00

abstract：:Single photons are of paramount importance to future quantum technologies, including quantum communication and computation. Nonlinear photonic devices using parametric processes offer a straightforward route to generating photons, however additional nonlinear processes may come into play and interfere with these sourc...

journal_title：Scientific reports

authors： Husko CA,Clark AS,Collins MJ,De Rossi A,Combrié S,Lehoucq G,Rey IH,Krauss TF,Xiong C,Eggleton BJ

更新日期：2013-11-04 00:00:00

abstract：:A dual-specificity, paralogue-free Cdc14 phosphatase was located in the nuclei of Beauveria bassiana (filamentous entomopathogen) and functionally characterized. Inactivation of cdc14 caused defective cytokinesis due to multinucleate cells formed in Δcdc14 and 89% decrease of blastospore production, followed by slower...

journal_title：Scientific reports

authors： Wang J,Liu J,Hu Y,Ying SH,Feng MG

更新日期：2013-10-30 00:00:00

abstract：:Mapping near-field profiles and dynamics of surface plasmon polaritons is crucial for understanding their fundamental optical properties and designing miniaturized photonic devices. This requires a spatial resolution on the sub-wavelength scale because the effective polariton wavelength is shorter than free-space exci...

journal_title：Scientific reports

authors： Du L,Lei DY,Yuan G,Fang H,Zhang X,Wang Q,Tang D,Min C,Maier SA,Yuan X

更新日期：2013-10-29 00:00:00

abstract：:We studied scattering and extinction of individual silver nanorods coupled to the J-aggregate form of the cyanine dye TDBC as a function of plasmon--exciton detuning. The measured single particle spectra exhibited a strongly suppressed scattering and extinction rate at wavelengths corresponding to the J-aggregate abso...

journal_title：Scientific reports

authors： Zengin G,Johansson G,Johansson P,Antosiewicz TJ,Käll M,Shegai T

更新日期：2013-10-29 00:00:00

abstract：:The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...

journal_title：Scientific reports

authors： Villano G,Ruvoletto M,Ceolotto G,Quarta S,Calabrese F,Turato C,Tono N,Crescenzi M,Biasiolo A,Cattelan A,Merkel C,Avogaro A,Gatta A,Pontisso P

更新日期：2013-10-28 00:00:00

abstract：:In spite of much work on topological insulators (TIs), systematic experiments for TI/TI heterostructures remain absent. We grow a high quality heterostructure containing single quintuple layer (QL) of Bi2Se3 on 19 QLs of Bi2Te3 and compare its transport properties with 20 QLs Bi2Se3 and 20 QLs Bi2Te3. All three films ...

journal_title：Scientific reports

authors： Zhao Y,Chang CZ,Jiang Y,DaSilva A,Sun Y,Wang H,Xing Y,Wang Y,He K,Ma X,Xue QK,Wang J

更新日期：2013-10-28 00:00:00

abstract：:The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is known to trigger the adaptive response by inducing the ada-regulon - consisting of three DNA repair enzymes Ada, AlkB, AlkA and the enigmatic AidB. We have applied custom designed tiling arrays to study transcriptional changes in Escherichia coli foll...

journal_title：Scientific reports

authors： Booth JA,Thomassen GO,Rowe AD,Weel-Sneve R,Lagesen K,Kristiansen KI,Bjørås M,Rognes T,Lindvall JM

更新日期：2013-10-25 00:00:00

abstract：:Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines to grow up to 4 times faster than other cell lines. The correlation of gene expression profiles with the growth rate in 60 different cell lines has been analyzed using several ...

journal_title：Scientific reports

authors： Feizi A,Bordel S

更新日期：2013-10-24 00:00:00

abstract：:Cysteine-rich receptor kinases (CRKs) belong to the receptor-like kinase family. Little is known about CRK genes in wheat. We isolated a wheat CRK gene TaCRK1 from Rhizoctonia cerealis-resistant wheat CI12633 based on a differentially expressed sequence identified by RNA-Sequencing (RNA-Seq) analysis. TaCRK1 was more ...

journal_title：Scientific reports

authors： Yang K,Rong W,Qi L,Li J,Wei X,Zhang Z

更新日期：2013-10-23 00:00:00

abstract：:Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...

journal_title：Scientific reports

authors： Vasanthi D,Nagabhushan A,Matharu NK,Mishra RK

更新日期：2013-10-22 00:00:00

abstract：:The ideal strategy for hair cell regeneration is promoting residual supporting cell proliferation followed by induction of hair cell differentiation. In this study, cultured neonatal mouse organs of Corti were treated with neomycin to eliminate hair cells followed by incubation with recombined adenovirus expressing Pa...

journal_title：Scientific reports

authors： Chen Y,Yu H,Zhang Y,Li W,Lu N,Ni W,He Y,Li J,Sun S,Wang Z,Li H

更新日期：2013-10-21 00:00:00

abstract：:Pellagra is a photosensitivity syndrome characterized by three "D's": diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a...

journal_title：Scientific reports

authors： Sugita K,Ikenouchi-Sugita A,Nakayama Y,Yoshioka H,Nomura T,Sakabe J,Nakahigashi K,Kuroda E,Uematsu S,Nakamura J,Akira S,Nakamura M,Narumiya S,Miyachi Y,Tokura Y,Kabashima K

更新日期：2013-10-17 00:00:00

abstract：:Here we proposed a novel architectural design of a ternary MnO2-based electrode - a hierarchical Co3O4@Pt@MnO2 core-shell-shell structure, where the complemental features of the three key components (a well-defined Co3O4 nanowire array on the conductive Ti substrate, an ultrathin layer of small Pt nanoparticles, and a...

journal_title：Scientific reports

authors： Xia H,Zhu D,Luo Z,Yu Y,Shi X,Yuan G,Xie J

更新日期：2013-10-17 00:00:00

abstract：:A typical assumption made in the existing opinion formation models is that two individuals can communicate with each other only if the distance between their opinions is less than a threshold called bound of confidence. However, in the real world it is quite possible that people may also have a few friends with quite ...

journal_title：Scientific reports

authors： Liu Q,Wang X

更新日期：2013-10-17 00:00:00

abstract：:The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the pri...

journal_title：Scientific reports

authors： Kerry PS,Mohan S,Russell RJ,Bance N,Niikura M,Pinto BM

更新日期：2013-10-16 00:00:00

abstract：:Sucralose is a widely-used artificial high-intensity sweetener. Although doubts have been raised about the safety of sucralose by several researchers, it can still be found in a broad range of foods and beverages worldwide, including in baked goods. Sucralose may decompose at high temperatures, and participate in chlo...

journal_title：Scientific reports

authors： Dong S,Liu G,Hu J,Zheng M

更新日期：2013-10-15 00:00:00

abstract：:Although autoantibody detection has been proposed for diagnosis of colorectal cancer, little is known about their initial production and development correlation with cancer progression. Azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice developed colon adenocarcinoma in the distal colon similar to human sporad...

journal_title：Scientific reports

authors： Barderas R,Villar-Vázquez R,Fernández-Aceñero MJ,Babel I,Peláez-García A,Torres S,Casal JI

更新日期：2013-10-15 00:00:00

abstract：:Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhanc...

journal_title：Scientific reports

authors： Kamanu TK,Radovanovic A,Archer JA,Bajic VB

更新日期：2013-10-15 00:00:00

abstract：:Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...

journal_title：Scientific reports

authors： Mondal S,Johnston JM,Wang H,Khelashvili G,Filizola M,Weinstein H

更新日期：2013-10-09 00:00:00

abstract：:We report highly efficient continuous-wave terahertz (THz) photoconductive antenna based photomixer employing nano-gap electrodes in the active region. The tip-to-tip nano-gap electrode structure provides strong THz field enhancement and acts as a nano-antenna to radiate the THz wave generated in the active region of ...

journal_title：Scientific reports

authors： Tanoto H,Teng JH,Wu QY,Sun M,Chen ZN,Maier SA,Wang B,Chum CC,Si GY,Danner AJ,Chua SJ

更新日期：2013-10-08 00:00:00

abstract：:Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular matrix (ECM) interactions as β-cells lose their native microenvironment. Herein, we built an ex-...

journal_title：Scientific reports

authors： Li W,Lee S,Ma M,Kim SM,Guye P,Pancoast JR,Anderson DG,Weiss R,Lee RT,Hammond PT

更新日期：2013-10-04 00:00:00

abstract：:We investigate the behaviour of the recently proposed Quantum PageRank algorithm, in large complex networks. We find that the algorithm is able to univocally reveal the underlying topology of the network and to identify and order the most relevant nodes. Furthermore, it is capable to clearly highlight the structure of...

journal_title：Scientific reports

authors： Paparo GD,Müller M,Comellas F,Martin-Delgado MA

更新日期：2013-10-04 00:00:00

abstract：:The electric field control of functional properties is an important goal in oxide-based electronics. To endow devices with memory, ferroelectric gating is interesting, but usually weak compared to volatile electrolyte gating. Here, we report a very large ferroelectric field-effect in perovskite heterostructures combin...

journal_title：Scientific reports

authors： Yamada H,Marinova M,Altuntas P,Crassous A,Bégon-Lours L,Fusil S,Jacquet E,Garcia V,Bouzehouane K,Gloter A,Villegas JE,Barthélémy A,Bibes M

更新日期：2013-10-03 00:00:00

abstract：:It is usually assumed that metabolic constraints restrict deep-sea corals to cold-water habitats, with 'deep-sea' and 'cold-water' corals often used as synonymous. Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 2...

journal_title：Scientific reports

authors： Roder C,Berumen ML,Bouwmeester J,Papathanassiou E,Al-Suwailem A,Voolstra CR

更新日期：2013-10-03 00:00:00

abstract：:We present a new general facile strategy for the preparation of protein-functionalized QDs in a single step at ambient conditions. We demonstrated that highly luminescent red to near-infrared (NIR) protein-functionalized QDs could be synthesized at room temperature in one second through a one-pot reaction that proceed...

journal_title：Scientific reports

authors： He X,Gao L,Ma N

更新日期：2013-10-02 00:00:00

abstract：:The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and pro...

journal_title：Scientific reports

authors： Cline MS,Craft B,Swatloski T,Goldman M,Ma S,Haussler D,Zhu J

更新日期：2013-10-02 00:00:00

abstract：:One procedure widely used to detect the velocity of a moving object is by using the Doppler effect. This is the perceived change in frequency of a wave caused by the relative motion between the emitter and the detector, or between the detector and a reflecting target. The relative movement, in turn, generates a time-v...

journal_title：Scientific reports

authors： Rosales-Guzmán C,Hermosa N,Belmonte A,Torres JP

更新日期：2013-10-02 00:00:00